5 Simple Statements About rheumatoid arthritis is an autoimmune disease Explained

A growing number of people across the globe suffer because their immune systems cannot more distinguish between healthy cells and invader micro-organisms. Instead of protecting themselves from disease, their organs and tissue are being attacked by these same defenses.




This issue is being tackled by large international research initiatives. One instance of this initiative is the London's Francis Crick Institute. Two world experts, James Lee (from the United States) and Carola Vinuesa (from Italy) have created separate research groups to pinpoint the root cause of the problem.


Lee told the Observer the Observer that autoimmune diseases increased in the west about 40 years ago. However, some cases are now being observed in countries that have never suffered from the disease.


The Middle East and East Asia are experiencing the greatest rise in the incidence of inflammatory bowel disorders. The patients had never encountered the disease prior to.


Autoimmune disorders range from type 1 diabetes to rheumatoid arthritis, inflammation of the bowel, and even multiple sclerosis. In each of these cases, the immune system gets its wires crossed, and it turns towards healthy tissue, not infectious agents.


The conditions have been identified by at least 4 million people living in the UK. Certain sufferers could suffer from multiple. It is estimated that autoimmune diseases are rising by 3% to 9% each year across the globe. The majority of scientists believe that environmental factors play a major role in this rise.


Lee who was previously in Cambridge University, says that our genetics haven't changed much over the last decade. So something must be changing around the world and it's increasing our susceptibility to the autoimmune disease.


Vinuesa who was located at the Australian National University, endorsed the idea. She spoke about the changes in diets that occurred when more countries adopted western-style diets and people ate more fast foods.


Vinuesa said that fast food meals contain a few essential ingredients, such as fiber. Evidence suggests that this can alter the microbiome of a person which is the accumulation of microorganisms living in our digestive tract. Microorganisms play a crucial role in controlling many bodily functions.


The microbiome's changes could then trigger autoimmune disorders. Over 100 kinds of autoimmune disorders have been identified.


The scientists both stressed that everyone is susceptible to developing these illnesses that include celiac, Lupus, and other ailments, such as celiac, that cause swelling and inflammation and can cause significant harm to different organs.


Vinuesa explained that autoimmune diseases aren't something you can get if you do not have a particular genetic susceptibility. "There isn't anything that we can do to stop the global spread of fast-food franchises. Therefore we're working to discover the basic genetic causes that cause the development of autoimmune diseases, and makes some people more susceptible than others. This is the method we are using to address the problem."


Scientists are now able to identify tiny differences in DNA between large numbers of people. This is possible because of new techniques. It allows us to discover the common genetic traits in those suffering from autoimmune diseases.


Lee said that until very recently we didn't have the tools needed to identify DNA. However, now we have this amazing power that has completely changed the way we do things. When I first began my research in the early 1990s, we knew only about half of the DNA variants that are involved in the development of an inflammatory intestinal condition. Over 250 of them are recognized.


Lee and Vinuesa have been involved in this research since the start of. Their efforts aim to uncover the various kinds of diseases that doctors Read More are currently investigating and to discover the genetic mechanisms that cause these types of diseases. Vinuesa said that autoimmune diseases such as Lupus, for instance, can be seen in many forms, and can have multiple genetic reasons. This is a problem when you are trying to find the right treatment.


There are many new therapies under development, and we don't know who we should give these to. Since we don't have a clear understanding of the exact cause of their illness, there are many choices. And that is now an important goal of the research arthritis rheumatoid treatment into autoimmune diseases. To ensure that we provide the best therapy we must be able to group and categorize patients.


Lee stated that the growing incidence of autoimmune diseases around the globe meant that innovative therapies and medications were needed urgently. There is currently no treatment for autoimmune diseases that are most often seen in young peoplewho are trying to get their first job, complete the school year, and also raise their families.


This means that more and more of people will have undergo surgery or receive regular injections. It can be devastating for patients, and put a massive pressure on healthcare. Therefore, it is crucial to find new, effective treatments.


Rheumatoid arthritis is an immuno-mediated disease. It's a mystery.


The antibodies your immune system produces to fight bacteria and viruses are essential to fight infection.


Your immune system might accidentally send antibodies to your joints if you have Rheumatoid. These antibodies attack the surrounding tissue.


This causes the thin layer, called synovium of cells that covers your joints to become painful. The synovium also releases chemicals that could cause injuries to the area.


bones

cartilage - the stretchy connective tissue between bones

Tendons are the connective tissue that connects bone to muscle

Ligaments - This is the tissue that connects bones and cartilage.

If rheumatoid arthritis is not treated, these chemicals gradually cause the joint to change shape and alignment. Eventually, it can destroy the joint completely.


There have been a variety of theories on why the immune system attacks joints. One theory is that an infection could trigger. But none of these theories has been proved.

Possible risk factors

Rheumatoid-related arthritis can result from a variety of factors, including:


It is possible to inherit it through your genes. While there are indications that rheumatoid arthritis could be passed down the generations, the chances of getting it are very low since genes only play a very minor role in the condition.

hormones. Rheumatoid arthritis can be more prevalent in women than men, which could be due to the impacts of the hormone estrogen, however, this connection hasn't been proven

There is evidence that smokers are more at chance of developing rheumatoid arthritis.